![]() Results: The transferrin-bearing lipidpolymer hybrid nanoparticles loaded with plumbagin resulted in the disappearance of 40 of B16-F10 tumors and regression of 10 of the tumors following intravenous administration.Ĭonclusion: These therapeutic effects, therefore, make transferrin-bearing lipidpolymer hybrid nanoparticles entrapping plumbagin a highly promising anti-cancer nanomedicine. ![]() Their therapeutic efficacy was evaluated in vivo after tail vein injection to mice bearing B16-F10 melanoma tumors. Their cellular uptake, anti-proliferative and apoptosis efficacy were assessed on various cancer cell lines in vitro. ![]()
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